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DNA Detection

Glucose Detection

Virus Detection

Biomolecule Products

The Sensation™ detection platform will simplify and expand the use of biomolecule analysis through easy-to-use, point-of-care products.  A disposable cartridge is interrogated using a small handheld electronic reader, providing diagnostic information in minutes instead of days. 

Nanōmix biodetection solutions provide routine access to critical information by simplifying conventional test protocols for medical professionals.  Current laboratory-based test methods are complex, time-consuming, and expensive which limits access to quantitative, time-sensitive diagnostic information. 

Detection devices made with Nanōmix’ proprietary random networks of carbon nanotubes are ultra sensitive and inexpensive to produce. 

Single or multianalyte detection is performed using the Sensation™ detection platform with minimal sample pre-treatment. No target amplification, such as PCR, will be required for the Sensation™ detection platform.

The Sensation™ platform :

• Enables measurement of small changes in electronic characteristics, allowing ultra-sensitive detection
• Has high specificity and reproducibility with the ability to select a desired dynamic range
• Eliminates the need for expensive labeling chemistries and optical equipment
• Enables small, automated handheld devices that allow point-of-care detection of biomolecules
• Provides for detection of nucleic acids and proteins on the same platform
• Provides multiplex capabilities in a simple on-chip assay
• Moves testing from clinical laboratories to the bedside, making it faster, simpler and far less expensive

Detection Applications:

• DNA*: The Sensation™ detection platform has been used to perform single base-pair mismatch human SNP detection using un-amplified, genomic DNA samples.  Direct, label free electronic detection has been achieved in low femtomolar concentrations through sponsored studies.  Nanōmix is currently developing an on-chip, Label-free, Isothermal Signal Amplification approach, known as LISA, to reduce sample complexity and lower the limit of detection down to the attomolar concentration range.  Planned user applications include electronic detection of Genetically Modified Organisms (GMO) in crop samples, and detection of human genetic patterns for diagnosis of infectious diseases, inherited diseases, and drug metabolism.
  
  
• Protein*: Multiple proteins are detected in sub ng/ml concentration levels using highly specific antibody chemistry on the same platform detection device.  A wide variety of high value point-of-care applications exist including the diagnosis of conditions such as stroke or heart attack through detection of biomarkers, tracking of fertility and diagnosis of pregnancy through hormone detection, and many more.
  
  
• Glucose*: Nanōmix is developing a nano-ink for glucose test strips that will provide less expensive test strips for standard glucose test meters along with valuable performance benefits.  A more consistent electrochemical response provides superior lot-to-lot consistency, enabling significantly lower manufacturing costs.  Carbon nanotube networks enable lower applied potentials, which significantly reduce electrochemically generated interfering substances resulting in better accuracy in low-end glucose concentrations.
  

*These products have not yet been cleared for medical use by the Food and Drug Administration (FDA) in the United States or by the appropriate regulatory authorities in Europe.

Publications
Click here to view our publications.

Recent research results on DNA hybridization using carbon nanotube network field-effect transistors have been published in the Jan. 24, 2006 issue of the Proceedings of National Academy of Sciences. “Feasibility has been established for a range of commercial opportunities related to detection of DNA, RNA, glucose, virus and protein bio molecules” says CEO David Macdonald. Read the full article here...